SINGLE-PARTICLE TRACKING DATASET

COMING SOON

Investigating the dynamics of various transcription factors and chromatin regulators.

spt.png

MICRO-C DATASET

Data is available at Higlass 3D genome browser and 4DN data portal.

COHESIN RESIDENCY DETERMINES CHROMATIN LOOP PATTERNS

​Budding yeast

  1. A364 WT

  2. mcd1-AID

  3. brn1-AID

  4. wpl1-AID

  5. pds5-AID

  6. Time courses released from G1-arrest

Graphical_Abstract_eLIFE-2020.png

RESOLVING THE 3D LANDSCAPE OF TRANSCRIPTION-LINKED MAMMALIAN CHROMATIN FOLDING

Mouse embryonic stem cells

  1. WT

  2. Flavopiridol

  3. Triptolide

Graphical_Abstract_MolCell-2020.png

ULTRASTRUCTURAL DETAILS OF MAMMALIAN CHROMOSOME ARCHITECTURE


Graphical_Abstract_MolCell-2020-2.png

3D ATAC-PALM: SUPER-RESOLUTION IMAGING OF THE ACCESSIBLE GENOME

Mouse embryonic stem cells

  1. WT

  2. CTCF-AID

Screen Shot 2021-01-22 at 1.56.39 PM.png

DISTINCT CLASSES OF CHROMATIN LOOPS REVEALED BY DELETION OF AN RNA-BINDING REGION IN CTCF

Mouse embryonic stem cells

  1. WT

  2. CTCF-RBRi deletion

Graphical_Abstract_MolCell-2019.jpg

TRANSFER RNA GENES AFFECT CHROMOSOME STRUCTURE AND FUNCTION VIA LOCAL EFFECTS

Budding yeast

  1. tDNA2334 strain

  2. tDNA690 strain

Screen Shot 2021-01-22 at 2.05.12 PM.png

MICRO-C XL: ASSAYING CHROMOSOME CONFORMATION FROM THE NUCLEOSOME TO THE ENTIRE GENOME

Budding yeast with various crosslinking conditions in the insoluble and soluble fractions

  • 1% FA + DSG/EGS

  • 3% FA + DSG/EGS

Fission yeast with various crosslinking conditions in the insoluble and soluble fractions​

  • 3% FA + DSG/EGS

xl.png

MAPPING NUCLEOSOME RESOLUTION CHROMOSOME FOLDING IN YEAST BY MICRO-C

Budding yeast
Various treatments including diamide and thiolutin, and mutations including med1d, rnh201d, rpd3d, rtt109d, top1d, ssu72-2, rgr1-100, rsc8-21, scc2-4, sth1-2 H4d4-14, H4K16Q, H4Q93E, H4R23A,

Graphical_Abstract_Cell-2015.png

Get in touch to learn more about our published research.

HISTONE MODIFICATION DATASET

HIGH-RESOLUTION CHROMATIN DYNAMICS DURING A YEAST STRESS RESPONSE

Comprehensive ChIP-seq data for histone modifications in budding yeast.

Screen Shot 2021-01-22 at 2.25.40 PM.png